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PMC 8675198
One hundred days is a generous window - most supplement brands offer 30 to 60 days - and it is specifically relevant here because the recommended evaluation period of four to eight weeks fits comfortably inside that return window

PubMed DOI Gwyer D, Wragg NM, Wilson SL

We also saw a case where methyl B12 successfully treated a 32 year-old man suffering from recurrent hypersomnia for 12 years

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This may point again to tissue fragility in people with clEDS
