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The enzyme methionine synthase needs methylcobalamin as a cofactor

In the CNS, thiamine deficiency can lead to Wernickes encephalopathy, characterized by nystagmus, ophthalmoplegia, mental status changes, and unsteady stance and gait, due to apoptotic cell death in sensitive brain areas, mainly areas with high metabolic requirement, causing symmetrically distributed lesions among structures such as the third and fourth ventricles, besides dorsomedial thalamus (, , )

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Our nutrition pros especially appreciate that this supplement is United States Pharmacopeia (USP) verified, meaning that it has passed rigorous testing to ensure quality and purity