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In a clinical or research setting, scores are calculated before and during/after treatment, and efficacy is determined according to the % reduction in the score

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Future research should emphasize the development of organ-specific delivery strategies, long-term toxicity assessment and clinical biomarker validation to guide patient selection and therapeutic monitoring

C.De BenedettoM.et al (2019)

It is a regulatory safety evaluation, not a drug approval hearing

Biochem Soc Trans 34, 711, 10.1042/BST20060007 (2006)
