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Animal models The pre-clinical studies can be misled by the animal models lacking the ability to reproduce the patient conditions, resulting in the failure of clinical trials [11]
The exception to this rule is the enzyme quiescin sulfydryl oxidase (QSOX
J Intern Med 286(1):3240 Brydges CR et al (2021) Indoxyl sulfate, a gut microbiome-derived uremic toxin, is associated with psychic anxiety and its functional magnetic resonance imaging-based neurologic signature
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