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While the loss of LIG3 in the nucleus can be generally compensated by the other DNA ligases, mitochondrial LIG3 is indispensable for mtDNA replication and repair [132, 133]

In recent years independent testing of consumer peptides bought online has repeatedly found a significant proportion failing basic quality checks, with live bacteria, heavy metals and bacterial endotoxin (which can cause serious illness and even death) being present in samples

Increased prevalence of primary biliary cirrhosis near Superfund toxic waste sites, (in eng)

Nat Rev Immunol (2005) 5(8):64154

Conversely, Nrf2 inhibition blocks antioxidant gene activation, resulting in ROS accumulation, macromolecular damage, and cell death

40 (4), e12990 (2024)