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Certain populations face higher deficiency risk: vegetarians and vegans (B12 is primarily found in animal products), adults over 50 (decreased stomach acid reduces B12 absorption), individuals with digestive disorders like Crohn's disease or celiac disease, and those taking medications like metformin or proton pump inhibitors

Mucins exist in two forms: transmembrane mucins are linked to the surface, and secreted mucins form a 3-dimensional network in the intestinal lumen

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GLP-1R/GIPR/GCGR Triple-Agonists Treatment Tri-agonist analogs, which activate the glucagon, GLP-1, and GIPRs, have been developed with the aim that the additional GIP activity will further offer better protection from glucagon-induced hyperglycemia

[DOI] [PMC free article] [PubMed] [Google Scholar] 35.Schwartz DM, Pehlivaner Kara MO, Goldstein AM, Ott HC, Ekenseair AK