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G., Zwahlen, M

Psychosocial Factors in Pain Management Pain is influenced by psychological and social factors, alongside physical injury

Steroid glycoside alkaloids [220], which can cause iron overload and redox imbalance in Calu-1 and A549 cells, and then trigger ferroptosis [221]

Spatial metabolomics analysis suggested its antifibrotic effect may be partially attributed to modulation of arginine biosynthesis and the metabolism of alanine, aspartate, and glutamate [131]

Animal experiments further revealed that cerebral hypoperfusion triggers a series of molecular and cellular events: insufficient brain perfusion first leads to dysfunctional mitochondrial energy metabolism, subsequently inducing excitotoxicity (primarily mediated by the overactivation of NMDA/AMPA receptors), and ultimately resulting in neuronal dysfunction and death [427]

The GATM and GAMT genes are expressed in neural tissues