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Ageing adversely affects the migration and function of marginal zone B cells

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(152) evaluated the protective effects of EODF on pentylenetetrazol-induced epilepsy rats through behavioral evaluation and histopathological examination and found that EODF reduced the density of black neurons in the hippocampal CA1 and CA3 regions and reduced the number of TUNEL-positive neurons in the hippocampus

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Since the melatonin exhibits its action through the involvement of various molecular pathways, the most described pathways involve activation of specific membrane receptors namely ML1 i.e., high affinity and low affinity i.e., ML2 sites (Dubocovich 1995