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Carnitine absorption from the intestinal tract and reabsorption from the kidney are mainly controlled by the plasma membrane OCTN2, which shows the highest affinity for carnitine among other transporters

Unfortunately, due to excess metabolism of l-carnitine by microorganisms in the small intestine, exogenous supplementation with oral l-carnitine has proved ineffective

Now that we understand how exactly TMA is produced in the gut and that the enzyme can be inhibited, there are grounds for further research into future discovery of drugs targeting the TMA-producing enzyme in the human gut