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Growing evidence underscores a complex crosstalk between ferroptosis and other key cellular processes, including metabolic reprogramming, autophagy, and immune regulation, all of which collectively shape ferroptosis susceptibility

T-cell death as a barrier to sustained antitumor immunity Beyond functional exhaustion and the complex signaling networks that regulate T-cell activity, the physical elimination of tumor-reactive T cells within the TME represents a criticalyet often overlookedmechanism that limits the durability of antitumor immunity

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A computer-based, systematic search was conducted on the PubMed database, and ensuing data from included articles was analyzed and discussed in this review

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