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Role of Cysteine S-Conjugate -Lyase in the Metabolism of Cisplatin

During the aging process, the expression of NRF2dependent antioxidant enzymes decreases, thereby leading to oxidative stress and related diseases [176]
The validation cohort was analyzed on an Evosep One (Evosep Inc., Odense, Denmark) liquid chromatography system coupled to an Orbitrap Exploris 480 mass spectrometer (Thermo Fisher Scientific, Bremen, Germany)
In the redox reaction catalyzed by glutathione peroxidase (GPX), GSH is converted to glutathione disulfide (GSSG), which can be reconverted to GSH by the enzyme glutathione reductase (GR)

A higher level of protein expression does not necessarily improve the GSH efflux stimulation

Neuro-oncology (2020) 22(2):18094