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Inflammatory cells, cytokines, CXC chemokines, signaling pathways, and other elements make up the tumor microenvironment (TME), which is characterized by inflammation

In terms of the relationship with obesity, studies have found that in obese humans and rodent models, autonomic imbalances include excessive activation of the vagus nerve (99, 100), and a decrease in the mass of WAT is induced after vagus nerve resection (100)

In other words, metabolic evidence of B vitamin deficiency must be present at the beginning of the intervention

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