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Age, sex, nutritional status, adiposity, dietary preferences, habits such as smoking, use of concurrent medications, physiologic states such as pregnancy, pathologic states such as liver disease, and others can affect one or more of the 3 processes listed above, thereby influencing the half-life of psychotropic and other drugs

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This is why ex vivo findings need to be confirmed in human trials which subsequent studies like the 2016 GHK peptide clinical trial and the 2021 copper tripeptide serum trial have done