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Testosterone can enlarge the prostate gland, which surrounds the urethra (the tube that drains urine from the bladder)

discovered that in negative ion mode MALDI-MS, 1,2-dioxetanes can undergo electron transfer-induced fragmentation, leading to intramolecular charge transfer-induced chemiluminescence (CTICL)

this latter would then phosphorylates S363 and triggers desensitization (Hong et al., 2009)

Paterson, D

doi: 10.1080/13547500400024768

In the first step, enzymes such as cytochrome P450 monooxygenases catalyze various reactions (oxidation, reduction or hydrolysis) to expose or introduce a functional moiety on hydrophobic substrates