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Omega-3 fatty acids (2-4g daily) support cardiovascular health during metabolic changes and may enhance insulin sensitivity

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There is no evidence that doses above 500mcg produce proportionally better results, and clinical trials using 1mg daily did not dramatically outperform lower doses

Monoamine reuptake modulation (Tesofensine): a small molecule originally studied in central-nervous-system research, of interest for its monoaminergic mechanism