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Scharping NE, et al

These changes are associated with reduced affinity for IGF-binding proteins and a prolonged active duration in experimental models

Demethylating agents can promote venetoclax-induced AML pyroptosis by restoring GSDME expression, offering a potential strategy to overcome resistance to BCL-2 inhibitors (14)

However, it is worthwhile to be alert to the risks associated with topical administration procedures, such as pump pocket complications, catheter or arterial complications, toxic or ischemic complications (Strnad et al., 2021), bowel obstruction, bleeding, abdominal pain (Alyami et al., 2019), and complications related to postoperative management (Hbner et al., 2020)