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Many children on the autism spectrum experience nutrient depletion for various reasons, including selective eating habits, poor absorption, or chronic stress affecting mineral levels

In multiple rodent models of chronic stress (a shared risk factor for major psychiatric illnesses), administration of LAC leads to a rapid and persistent antidepressant-like response by increasing histone acetylation and expression of key genes, including mGlu2 receptors and the downstream brain-derived neurotrophic factor BDNF [27, 30, 34,35,36,37]

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While L-carnitine shows some evidence in previous studies conducted with migraine in combination with other supplements, additional studies are needed to confirm the role of ALA as monotherapy and in combination with L-carnitine