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Numerous attempts have been made to address the underlying mechanisms therapeutically, but the quantifiable benefits remain limited

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PATHOPHYSIOLOGY AND MECHANISMS Migraine is a complex and disabling neurological disorder, more prevalent in women, whose pathophysiology involves neurovascular mechanisms, mitochondrial dysfunction, neurogenic inflammation, and oxidative stress

428 Peripheral nociceptor terminals respond to noxious stimuli via an array of receptors and ion channels to initiate an action potential

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Abu Ahmad, N, et al, l-Carnitine improves cognitive and renal functions in a rat model of chronic kidney disease. in Physiology & Behavior, Volume 164, Part A, October 2016, pp 182 - 188