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This G-protein signaling bias, which we confirmed across multiple assay platforms (cAMP inhibition, -arrestin-2 recruitment, [ 35 S]GTPS binding), distinguishes kratom alkaloids from classical opioids like morphine and fentanyl that strongly recruit -arrestin-2

[DOI] [Google Scholar] 31.Kalra S., Aggarwal S., Khandelwal D

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