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KEYWORDS: Trimethylamine N-oxide, flavin monooxygenase 3, trimethylamine lyase Introduction: TMAO as a therapeutic target Trimethylamine N-oxide (TMAO) is increasingly recognized as a crucial microbial metabolite linking diet, the gut microbiota, and systemic diseases, particularly those affecting cardiovascular and metabolic health

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It also increases the rate at which the liver oxidizes or uses up fats as an energy generating process and thus is a nutrient that protects us from cardiovascular disease by reducing blood triglycerides and raising the good HDL cholesterol levels