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Clinical trials measuring body composition found that fat mass reductions occurred without corresponding increases in lean tissue mass, confirming the absence of anabolic muscle-building effects

In fat cells, 5-amino-1MQ lowered the NNMT byproduct 1-methylnicotinamide (EC50 near 2.3 micromolar) and cut fat storage, without disturbing the other enzymes in the NAD+ salvage pathway

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The total annual cost for intramuscular injections for cohort 2 was $1.6 million (Table 3)

Author contributions MM: Conceptualization, Formal Analysis, Validation, Writing review and editing

5-Amino-1MQ is supplied in a lyophilized (freeze-dried) form to support stability during transportation and storage