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This suggests that extrapolation of pharmacokinetic studies from laboratory animals to humans is of limited validity and should always be done with caution

Nanoformulation of Olaparib Amplifies PARP Inhibition and Sensitizes PTEN/TP53-Deficient Prostate Cancer to Radiation

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Supplementary Material Abbreviations: AE = adverse event BA = bone age FAS = full analysis set GH = growth hormone IGF-1 = insulin-like growth factor-1 IGFBP-3 = insulin-like growth factor binding protein-3 IRB = Institutional review board PAH = predicted adult height SD = standard deviation SDS = standard deviation score This work was supported by the Korea Ginseng Corporation, Daejeon, Republic of Korea [grant number: KGCANTLER2021]

This toxicity is the most common cause of acute liver failure in the United States, resulting in an estimated 56,000 hospital visits each year