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elegans GST genes showed that knockdown of five, which included one pi ( gst-10 ) and four sigma isoforms ( gst-5 , gst-6 , gst-8 , and gst-24 ), sensitized the worms to exposure to the lipid peroxidation product, 4-hydroxyneoneal (4-HNE) [122]

N Engl J Med 391 , 19241935

640 Gallic acid treatment can alleviate depression-like behaviors and pain, and the mechanism may be related to inhibiting ferroptosis by regulating the P2X purinoceptor 7 (P2X7)-ROS signaling pathway in spinal microglia

However, the current research on caffeine dosage remains controversial

Lou E, Fujisawa S, Morozov A, Barlas A, Romin Y, Dogan Y, Gholami S, Moreira AL, Manova-Todorova K, Moore MA