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doi: 10.1001/archneurol.2011.149

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Evidence shows that isolated leucine supplementation becomes ineffective, and may even have unfavorable consequences, when other essential amino acids are limited or when systemic amino-acid dysregulation is present

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Notably, in the occasional meat eater group, the FC of TMAO decreased after the treatment intervention, in contrast to the observed increase in the regular meat eater group

Mohammadi et al ., 2004b[75])
