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Next, invest in contact-site biology by creating tools and reference atlases that resolve microdomain redox at organelle interfaces (MAMs, peroxisomemitochondria, mitochondrialysosome) and plasma-membrane nanodomains, because that is where signalling turns into damage (Xia et al

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This mechanism is completely distinct from growth hormones receptor-mediated actions and explains how AOD-9604 can provide fat metabolism benefits without systemic hormonal effects