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The increased urea induces the decreased expression of tight junction proteins, including claudin-1, occludin and zonula occludens-1 (ZO-1), which results in the disruption of intestinal epithelial tight junction (Vaziri et al., 2013)

Together, these findings highlight the Goldilocks role of ROS: too little fails to induce effector T cell formation and instead promotes Tregs, whereas excessive or prolonged ROS drives exhaustion and apoptosis

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A mouthwash containing curcumin was also found to be as effective as chlorhexidine in reducing inflammation in individuals who underwent periodontal therapy for gingivitis (93)