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Starting from day 8 post-induction, Lewis rats were given piperine (0, 20, 40, and 80 mg/kg-P.O.) or prednisolone (10 mg/kg-P.O.) for 18 consecutive days

Consequently, mitochondrial dysfunction exacerbates oxidative stress, impairs mitochondrial DNA (mtDNA) or deletions of mtDNA, increases intracellular Ca2+ levels, changes in fission/fusion and mitochondrial morphology, and lastly leads to neuronal death

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Improved Skin Radiance: Enhances overall skin brightness and reduces dark spots

Against pigment spots and for radiance: Niacinamide, glutathione and vitamin C help reduce dark spots and brighten the complexion

S-Acetyl Glutathione