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Physiopathological consequences with clinical expression have been observed in different systems, such as that recently found by Chang-Hoon et al., in which patients with fatty liver had lower lung function as measured by FVC [45]

Another metabolite, Neu5Ac, has been shown to promote endothelial ferroptosis via the SLC3A2 pathway, contributing to endothelial cell injury and accelerating atherosclerotic plaque progression in Apoe-/- mice [112]

461,462 Epigenetic drugs in clinical trials for HCC include DNMTi and HDACi, most of which are in combined with other therapies