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In a recent review, S Ma et al., 2020, have discussed in details the therapeutic potential of picroside-II for organic ischemia and reperfusion injury (to organs and tissues such as cerebrum, myocardium, kidney, testes, skeletal muscles and erythrocytes), liver damage, inflammation, cancer metastasis and osteoclastogenesis

131 The system, termed LNC-Ted HAKPV, offered three principal therapeutic benefits: (1) promotion of endogenous GLP-2 production to enhance intestinal growth and repair, (2) targeted anti-inflammatory action mediated through HA-KPV's modulation of the CD44/TLR4 pathways, and (3) redox-responsive release of the anti-inflammatory tripeptide KPV via disulfide bonds, activated under inflamed intestinal conditions

Wong HC, Zhang Q, Beirl AJ, Petralia RS, Wang YX, Kindt K