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A meta-analysis of 8 RCTs found that NAC supplementation significantly reduced fasting glucose (WMD: -5.84 mg/dL) and HbA1c (WMD: -0.27%) in people with metabolic conditions (Sarkaki et al., Clin Nutr ESPEN, 2021) [57]

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p K a Prediction in Nonaqueous Solvents K a values in nonaqueous solvents are typically predicted from first-principles calculations using the isodesmic method

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