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Early evidence of the impact of cannabis legalization on cannabis use, cannabis use disorder, and the use of other substances: Findings from state policy evaluations

Similar content being viewed by others Introduction Sickle cell disease (SCD) is an inherited hematological disorder caused by an A to T mutation in the adult -globin gene with the product of hemoglobin S which polymerizes under hypoxia conditions 1,2

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Succinate accumulation inhibits -KGdependent TET and JMJD demethylases, promoting DNA and histone hypermethylation, whereas reduced -KG availability further constrains demethylation and limits enhancer plasticity

Translation of rabbit globin mRNA introduced by liposomes into mouse lymphocytes