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Finally, prospects for ferroptosis-based interventions and future directions point to several promising treatment avenues, including regulating iron homeostasis via chelators or TfR1/FPN modulation, using antioxidants and lipid peroxidation inhibitors to target GPX4 and ACSL4, or employing gene therapies and stem cell/exosome approaches to combat ferroptosis

doi: 10.3389/fphys.2017.00097 260 BinnewiesMRobertsEWKerstenKChanVFearonDFMeradMet al

Firstly, gastrointestinal absorption naturally becomes less efficient with advancing age, which results in reduced cellular uptake of nutrients

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290 V-9302, an inhibitor of Gln transporter SLC1A5, increases intracellular ROS and autophagosome production