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It has been reported that lung cancer cells exhibit upregulated expression of all key glycolytic enzymes [hexokinase 2 (HK2), phosphofructokinase and pyruvate kinase (PK)] (13), suggesting that the essential enzymes of the aerobic glycolytic pathway have a critical role in the development of lung carcinoma

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This point is important for genetic counseling, because an individual with mild clinical findings can have a child with a more severe phenotype, or vice versa

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At 24, 48 and 72 hours, glutathione synthetase activity increased in susceptible plants, but the increase was of a much smaller magnitude in comparison with that observed in resistant plants

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In an extended view, in the homocysteine degradation process, NAD + is a cofactor of 5,10-methylenetetrahydrofolate reductase (MTHFR), which catalyzes the reduction of 5,10-methyleneTHF into 5-methyltetrahydrofolate [45]

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