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Furthermore, ascorbate levels rose across the board in all tumor areas, indicating that enhanced Vit-C plasma availability enabled efficient accumulation throughout the tumor

Photosynthetica 46:410419 Meister A (1995) Glutathione biosynthesis and its inhibition

Increased oxidative stress is also associated with neuronal cell death during the pathogenesis of multiple chronic neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), and amyotrophic lateral sclerosis (ALS)

Since only the leak pathway varies with inflammation, this concept provides a solid foundation for the use of the above-described ratio measurements, in that the pore pathways transport the small molecules such as mannitol or 400 (Da) fluorescein isothiocyanate (FITC) 400 whereas larger molecules such as lactulose and FITC 4000 are transported by the variable leak pathway