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Wichman J, Winther KH, Bonnema SJ, Hegeds L (2016) Selenium supplementation significantly reduces thyroid autoantibody levels in patients with chronic autoimmune thyroiditis: a systematic review and meta-analysis

Such regulation occurs primarily at multiple levels, including DNA methylation, histone modifications, and non-coding RNAs (115)

Klicek R, Sever M, Radic B, et al

This concern arises from the fact that studies of hGH have shown that long-term exogenous administration, while increasing lean body mass and decreasing adipose tissue, can also cause: increased insulin resistance, diabetes, acromegaly, cancer, hypertension (high blood pressure), and edema (swelling)
Singh S

The internet is a sprawling echo chamber of opinions on this, ranging from dismissive confidence to outright alarm