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The use of biomarkers for oxidative stress may provide further evidence of a causal relationship between oxidative damage to macromolecules (DNA, lipids, and proteins)

All in all, astrocytic responses in AD are complex and disease stage-specific: in the early, compensated phase of AD (manifested by mild cognitive impairment) astrocytes, together with other neuroglia become reactive and arguably protect brain tissue

Publications regarding such only have surfaced in the past few years

Prog Neuropsychopharmacol Biol Psychiatry 79:340

After 30, testosterone begins to decline slowly

Nesch et al
