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AOD-9604 does have a coherent proposed mechanism one grounded in the lipolytic biology of growth hormone and supported by a small set of rodent and cell studies from the late 1990s and early 2000s but that mechanism is largely preclinical , and the compounds one serious test in humans, a pivotal obesity trial, failed to separate it from placebo

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Just as GLP-1 in the body naturally does, GLP-1 medications work by: Stimulating insulin secretion, which allows cells to take up sugar Inhibiting the release of glucagon , which helps lower blood sugar levels Slowing stomach emptying, which can help prevent a post-meal sugar spike , as sugar from food is released more slowly into the bloodstream Increase how full you feel after eating Along with blood sugar management, these medications are also beneficial for weight management and reducing the risk of heart and kidney problems

The trade-off is real