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These individuals include pregnant and breastfeeding women

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If stopping mid-cycle due to side effects or logistical constraints, taper isnt necessarysimply discontinue both compounds and allow the standard washout period before restarting

Early diagnosis and treatment typically lead to better outcomes

The most robust theory is that metformin disrupts the B12-intrinsic factor (IF) complex uptake at the ileal cell surface receptor (Cubilin receptor) which is known to be calcium dependent