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The involvement of these distant organs in IR injury significantly complicates clinical outcomes, increasing the risk of multi-organ failure and underscoring the need for targeted therapeutic interventions

First, optimal dosing in humans remains undefined, with current practice based primarily on extrapolation from animal studies and anecdotal clinical experience rather than formal dose-finding studies

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Cette vitamine B12 va alors se lier au facteur intrinsque , aussi appel facteur intrinsque de Castle, en lhonneur du scientifique William Castle, que nous avons dj mentionn et qui a ralis des travaux importants sur le sujet