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Additionally, GSTM1 is a negative regulator of ASK1, a kinase involved in the apoptotic pathway [49]

[DOI] [PubMed] [Google Scholar] 48.Yue LM, Lee J, L ZR, et al

Nrf2-regulated glutathione recycling independent of biosynthesis is critical for cell survival during oxidative stress

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Collectively, these multifaceted interactions emphasize the critical roles played by gut microbiota in the etiology and progression of hypothyroidism, underscoring the therapeutic potential of targeted microbiota interventions, including probiotics, prebiotics, dietary adjustments, and lifestyle modifications, to restore microbiome equilibrium and mitigate hypothyroid pathology