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Stage 3: Method-of-Use Patent Expansion (Years 5-20 from NDA) Post-approval clinical research frequently generates new uses for approved drugs, either as single agents in new indications or as components of combination regimens
In 2020, Bastola and colleagues found a significant positive association between serum selenium concentrations and hypertension based on the data from 6,683 participants in the NHANES (20112016)
