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Accessed March 5, 2021

Inhibitors of caveolar endocytosis could potentially selectively target MFI2-dependent iron uptake in tumors with high MFI2 expression while sparing normal cells that primarily use transferrin receptor-mediated iron acquisition

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To gain insight into the role of DMH-projecting vlPOA VGAT neurons in hypothermia induction, we transduced GABAergic neurons located in the vlPOA of Vgat-cre mice by administering a Cre-dependent rAAV2/1-EF1a-DIO-hChR2(H134R)-EYFP-WPRE-HGHpA vector

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E2F activates the transcription of pro-S phase cell cycle genes, promoting G1/S phase transition ( In families without mutations in CDKN2A and CDK4 genes, the use of NGS methodologies has allowed the identification of rare germline mutations in a few novel melanoma susceptibility genes, namely BRCA1 Associated Protein 1 (BAP1), TERT , Protection of Telomeres 1 ( POT1 ), ACD Shelterin Complex Subunit and Telomerase Recruitment Factor ( ACD ), TERF2 Interacting Protein ( TERF2IP ) (high risk genes) and MC1R, MITF (low to moderate risk genes)