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471 According to the PAKT trial, the addition of the AKT inhibitor capivasertib to the first-line paclitaxel therapy for TNBC resulted in significantly longer PFS and OS, especially in tumors with PIK3CA/AKT1/PTEN alterations

doi: 10.1214/19-AOS1866 37

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Proton pump inhibitor and histamine 2 receptor antagonist use and vitamin B 12 deficiency
Neurosurgical Focus 38 , E10 (2015)

High B12 is not usually dangerous on its own, but may point to issues like liver disease, kidney dysfunction, or blood cancers
