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Physiopathological functions of GPx and associated diseases The increase of ROS has been associated with the appearance and progression of aging and related diseases including arthritis, diabetes, dementia, cancer, atherosclerosis, and vascular diseases, which are inflammatory disorders, a consequence of oxidative stress [54, 55]
3.3 Ferroptosis and necroptosis Historically, apoptosis was widely regarded as the sole mechanism of programmed cell death, with necrosis dismissed as a chaotic and unregulated phenomenon
3.2.3 Mechanism of antioxidant system dysfunction-mediated ferroptosis involved in intracerebral hemorrhage Various antioxidant pathways can inhibit ferroptosis and may serve as effective targets for protecting against ICH (Figure 2C)
BMC Psychiatry 20 , 63 (2020)
S.BruntonJ
Diosmin mitigates gentamicin-induced nephrotoxicity in rats: Insights on miR-21 and-155 expression, Nrf2/HO-1 and p38-MAPK/NF-B pathways
