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As a result, the cell is able to accumulate high levels of ascorbic acid3
Published 2019 Aug 9

458 Treatment with eNAMPT can increase the expression of lipoprotein lipase and PPAR in preadipocytes and promote the expression of fatty acid synthase in differentiated adipocytes, which indicates that eNAMPT may be a positive regulator in adipocytes lipid metabolism

Acta Physiol (Oxf) 2021;232:e13644
2APB: 2-aminoethoxydipenyl-borate APAP: acetaminophen DAMPs: damage-associated molecular patterns DMSO: dimethyl sulfoxide GSH: glutathione LDH: lactate dehydrogenase LPO: lipid peroxidation MPTP: mitochondrial membrane permeability transition pore NAC: N -acetylcysteine NK: natural killer NNT: nicotinamide nucleotide transhydrogenase P-JNK: phosphorylation of c-jun N-terminal kinase PUFAs: polyunsaturated fatty acids ROS: reactive oxygen species SEC: sinusoidal endothelial cell HJ: Conceptualization, Writingoriginal draft, Writingreview & editing

Additionally, analyses of the gut microbiota in PD patients revealed dysbiosis characterized by a reduction of bacteria producing short-chain fatty acid which are crucial for maintaining the barrier integrity of the intestines 44,45
