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Among patients for whom ECOG PS (n=1722) and smoking history (n=1516) were collected, 65% had an ECOG PS of 1, 36% had an ECOG PS of 0, and 84% were smokers

Biological and Clinical Implications The SAM/SAH ratio is crucial in multiple biological contexts: Epigenetic Regulation : Since methylation is a key mechanism in epigenetic modifications, the SAM/SAH ratio directly affects gene expression patterns

The Enhanced expression of FAM98A recover 5-FU suppressed CRC cell proliferation both in vitro and in vivo by activating the translation of SLC7A11 in stress granules (He et al., 2022)

Conversely, methylation in K4 and K27 is involved in suppression of gene expression among chromosomal domains

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LRRK2 promotes TH expression and increases DA generation which can be aggravated by LRRK2 mutations, while WT PINK1 suppresses TH expression and DA generation, which can be abrogated by PD-linked PINK1 mutations [44]