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531 Both SIRT1 and SIRT3 exert their function through PGC-1, which acts as a modifier in HD and ALS patients and other models

MRP1/MRP2 chimeras construction A couple of unique restriction enzyme sites x and y in the ABCC1 gene of the pcDNA5/FRT-MRP1 vector were selected to surround a fragment A which includes the fragment B, corresponding to the sequence of ABCC1 to exchange by the sequence of ABCC2 (Supplementary Table 1)

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NAC, liposomal glutathione) or lifestyle changes are improving redox balance

Once formed, 5 methylTHF is used by methionine synthase for the vitamin B 12 -dependent conversion of homocysteine to methionine and the formation of THF ( Figure 2 )

a small molecule that remains preclinical and not approved