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Description
Regulation that occurs at the receptor level results in the progressive waning of signalling efficacy and is known as desensitization
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4.5.2 Autophagy modulators Chloroquine and hydroxychloroquine remain the most clinically tested autophagy inhibitors to date, due to their previous FDA approval as anti-malaria drugs
For other ADs, therapeutic potential has mainly been validated in animal or in vitro models, whereas human clinical data remain scarce and limited to small cohorts
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