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Liver Int 2011;31:507515

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preferential MC1R agonist driving eumelanin synthesis via cAMP/PKA/MITF pathway with enhanced DNA repair signaling

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A liver biopsy may be performed to confirm HCV infection and determine disease severity

However, they also find, as have others, that the activation of TRPC1 requires a direct interaction between STIM1 and TRPC1, in addition to the role of STIM1 in activating Ca 2+ entry through Orai1 channels