methylated b vitamins improve glutathion levels Methylation and Homocysteine B Vitamins and the Brain:
Description
Science 355 , eaai7825 (2017)

Oxidative stress underlies the pathophysiology of AMD [139]

Folate protects normal cells from mutations, but once initial DNA damage occurs, elevated folate levels can tip the balance towards the progression of neoplastic cells into cancer by promoting the increased synthesis of nucleic acids [164,170]

However, brain iron deficiency has been linked to the circadian disorder, restless leg syndrome, which is a compulsion to move ones legs when at rest, typically exacerbated at night [85]

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